Civic Engagement and People with Disabilities: A Way Forward Through Cross-Movement Building

This report presents a national overview of the barriers to civic engagement that disabled people experience. Drawing on our findings from surveys, a Twitter chat, and interviews, we offer recommendations for the philanthropic sector and for civic engagement organizations aspiring to create a more inclusive and responsive democracy to build civic power among people with disabilities. Civic power in this report is conceptualized as opportunities for people with disabilities to amplify, mobilize, and elevate their voices and infuence within democracy.This report centers the expertise, insights and lived experiences of people with disabilities, including leaders from various disability communities. Our findings reaffirm that no disability rights issue exists outside the sphere of civic engagement and no meaningful civic engagement strategy can emerge without attention to disability rights. Supported by the Ford Foundation's Civic Engagement and Government (CEG) program, this report is a collaboration between the Lurie Institute for Disability Policy and the Sillerman Center for the Advancement of Philanthropy, both based at Brandeis University's Heller School for Social Policy. The disability rights mantra "nothing about us, without us" informs the questions, methods and content in this report. We hope the findings and recommendations will inspire new thinking and action within philanthropy and civic engagement spaces, and spark courageous conversations and inform practices within the vital organizations working to strengthen democracy in the United States.

Using improved power electronics modeling and turbine control to improve wind turbine reliability

Improving offshore wind turbine reliability is a key industry goal to improve the availability of this renewable energy generation source. The semiconductor devices in the wind turbine power converter are traditionally considered as the most sensitive and important components to achieve this and managing their thermomechanical stressing is vital, since this is one of their principal long-term aging mechanisms. Conventional deterministic reliability prediction methods used in industrial applications are not suitable for wind turbine applications, due to the stochastic nature of the wind speed. This paper develops an electrothermal model of the power devices, which is integrated with a wind turbine system model for the investigation of power converter thermal cycling under various operating conditions. The model has been developed to eliminate the problems of pulse width modulation switching, substantially reducing simulation time. The model is used to improve the current controller tuning method to reduce thermal stresses suffered by the converter during a grid fault. The model is finally used to design a control method to alleviate a key problem of the doubly fed induction generator—severe thermal cycling caused during operation near synchronous speed

Distinct DNA methylation profiles in subtypes of orofacial cleft

Abstract Background Epigenetic data could help identify risk factors for orofacial clefts, either by revealing a causal role for epigenetic mechanisms in causing clefts or by capturing information about causal genetic or environmental factors. Given the evidence that different subtypes of orofacial cleft have distinct aetiologies, we explored whether children with different cleft subtypes showed distinct epigenetic profiles. Methods In whole-blood samples from 150 children from the Cleft Collective cohort study, we measured DNA methylation at over 450,000 sites on the genome. We then carried out epigenome-wide association studies (EWAS) to test the association between methylation at each site and cleft subtype (cleft lip only (CLO) n = 50; cleft palate only (CPO) n = 50; cleft lip and palate (CLP) n = 50). We also compared methylation in the blood to methylation in the lip or palate tissue using genome-wide data from the same 150 children and conducted an EWAS of CLO compared to CLP in lip tissue. Results We found four genomic regions in blood differentially methylated in CLO compared to CLP, 17 in CPO compared to CLP and 294 in CPO compared to CLO. Several regions mapped to genes that have previously been implicated in the development of orofacial clefts (for example, TBX1, COL11A2, HOXA2, PDGFRA), and over 250 associations were novel. Methylation in blood correlated with that in lip/palate at some regions. There were 14 regions differentially methylated in the lip tissue from children with CLO and CLP, with one region (near KIAA0415) showing up in both the blood and lip EWAS. Conclusions Our finding of distinct methylation profiles in different orofacial cleft (OFC) subtypes represents a promising first step in exploring the potential role of epigenetic modifications in the aetiology of OFCs and/or as clinically useful biomarkers of OFC subtypes

Supplier Management System

Supplier Management System (SMS) allows for a consistent, agency-wide performance rating system for suppliers used by NASA. This version (2.0) combines separate databases into one central database that allows for the sharing of supplier data. Information extracted from the NBS/Oracle database can be used to generate ratings. Also, supplier ratings can now be generated in the areas of cost, product quality, delivery, and audit data. Supplier data can be charted based on real-time user input. Based on these individual ratings, an overall rating can be generated. Data that normally would be stored in multiple databases, each requiring its own log-in, is now readily available and easily accessible with only one log-in required. Additionally, the database can accommodate the storage and display of quality-related data that can be analyzed and used in the supplier procurement decision-making process. Moreover, the software allows for a Closed-Loop System (supplier feedback), as well as the capability to communicate with other federal agencies

Just add sugar for carbohydrate induced self-assembly of curcumin

In nature, self-assembly processes based on amphiphilic molecules play an integral part in the design of structures of higher order such as cells. Among them, amphiphilic glycoproteins or glycolipids take on a pivotal role due to their bioactivity. Here we show that sugars, in particular, fructose, are capable of directing the self-assembly of highly insoluble curcumin resulting in the formation of well-defined capsules based on non-covalent forces. Simply by mixing an aqueous solution of fructose and curcumin in an open vessel leads to the generation of capsules with sizes ranging between 100 and 150 nm independent of the initial concentrations used. Our results demonstrate that hydrogen bonding displayed by fructose can induce the self-assembly of hydrophobic molecules such as curcumin into well-ordered structures, and serving as a simple and virtually instantaneous way of making nanoparticles from curcumin in water with the potential for template polymerization and nanocarriers.S.W. is grateful for UNSW PhD scholarship. J.H. acknowledges support from the Australian Research Council (DE160100807) and supercomputer resources from the NCI, Pawsey Supercomputing Centre and Intersect Australian Ltd. Finally, M.H.S. and C.J.G. would like to thank the Australian Research Council (ARC DP 160101172) for fundin

Photographed Rapid HIV Test Results Pilot Novel Quality Assessment and Training Schemes

HIV rapid diagnostic tests (RDTs) are now used widely in non-laboratory settings by non-laboratory-trained operators. Quality assurance programmes are essential in ensuring the quality of HIV RDT outcomes. However, there is no cost-effective means of supplying the many operators of RDTs with suitable quality assurance schemes. Therefore, it was examined whether photograph-based RDT results could be used and correctly interpreted in the non-laboratory setting. Further it was investigated if a single training session improved the interpretation skills of RDT operators. The photographs were interpreted, a 10-minute tutorial given and then a second interpretation session was held. It was established that the results could be read with accuracy. The participants (n = 75) with a range of skills interpreted results (>80% concordance with reference results) from a panel of 10 samples (three negative and seven positive) using four RDTs. Differences in accuracy of interpretation before and after the tutorial were marked in some cases. Training was more effective for improving the accurate interpretation of more complex results, e.g. results with faint test lines or for multiple test lines, and especially for improving interpretation skills of inexperienced participants. It was demonstrated that interpretation of RDTs was improved using photographed results allied to a 10-minute training session. It is anticipated that this method could be used for training but also for quality assessment of RDT operators without access to conventional quality assurance or training schemes requiring wet samples

What future/s for outdoor and environmental education in a world that has contended with COVID-19?

This is an unusual article in that it brings together the perspectives of many on this journal’s editorial board, around the issue of contending with COVID-19. Twenty statements showcase a range of thoughts and experiences, highlighting the differences and similarities in the way the pandemic is impacting on the educational practice of outdoor and environmental education. The future is not yet written, of course, so it is worth thinking about how the current moment may impact on the months and years to come. The aim of this article is to influence and support such thinking

Pathogenic variants in THSD4, encoding the ADAMTS-like 6 protein, predispose to inherited thoracic aortic aneurysm

Purpose Thoracic aortic aneurysm and dissection (TAAD) is a life-threatening disease with often unrecognized inherited forms. We sought to identify novel pathogenic variants associated with autosomal dominant inheritance of TAAD. Methods We analyzed exome sequencing data from 35 French TAAD families and performed next-generation sequencing capture panel of genes in 1114 unrelated TAAD patients. Functional effects of pathogenic variants identified were validated in cell, tissue, and mouse models. Results We identified five functional variants inTHSD4of which two heterozygous variants lead to a premature termination codon.THSD4encodes ADAMTSL6 (member of the ADAMTS/L superfamily), a microfibril-associated protein that promotes fibrillin-1 matrix assembly. TheTHSD4variants studied lead to haploinsufficiency or impaired assembly of fibrillin-1 microfibrils.Thsd4(+/-)mice showed progressive dilation of the thoracic aorta. Histologic examination of aortic samples from a patient carrying aTHSD4variant and fromThsd4(+/-)mice, revealed typical medial degeneration and diffuse disruption of extracellular matrix. Conclusion These findings highlight the role of ADAMTSL6 in aortic physiology and TAAD pathogenesis. They will improve TAAD management and help develop new targeted therapies